![]() ![]() The total phenolic contents (0.011–0.949 mg chlorogenic acid equivalent/g fw) were highly correlated with the hydrophilic-ORAC (R2 = 0.937) and DPPH (R2 = 0.820) values. However, the lipophilic-ORAC values were poorly correlated with the β-carotene contents (R2 = 0.480). The hydrophilic-ORAC values were significantly correlated with the DPPH (R2 = 0.859) and ABTS (R2 = 0.761) values. The total antioxidant activity (hydrophilic + lipophilic ORAC) was highest (27.2 μmol TE/g fresh weight (fw)) for NC415 (purple-fleshed) and lowest (2.72 μmol TE/g fw) for Xushu 18 (white-fleshed). Total phenolics were measured using the Folin–Ciocalteau method, total anthocyanins by the pH-differential method, and β-carotene by HPLC. KeywordsStatins-Simvastatin-Mitochondria-ToxicityĪntioxidant activities (μmol Trolox equivalent (TE)/g fresh weight) of 19 sweet potato genotypes with distinctive flesh colour (white, cream, yellow, orange and purple) were measured by oxygen radical absorbance capacity (ORAC), 2,2-diphenyl-1-picrylhydrazyl (DPPH), and 2,2′-azinobis(3-ethyl-benzothiazoline-6-sulfonic acid) (ABTS). Molecular mechanisms underlying simvastatin cytotoxicity are discussed. In this review some details about statins including theirĪdverse effects in humans and animals, the effects of simvastatin on various intracellular and mitochondrial processes, and With simvastatin therapy are uncommon, but potentially serious. Although statinsĪre generally safe, minor and severe adverse reactions are well known complications of statin use. Of hypercholesterolemia that constitutes the main origin of atherosclerosis, leading to coronary heart disease. ![]() Statin drugs represent the major improvement in the treatment Plasma cholesterol levels by decreasing the activity of this enzyme. Simvastatin is one of nine known statins, specific inhibitors of hepatic enzymeģ-hydroxy-3-methylglutaryl-coenzyme A reductase, the rate-limiting step of cholesterol biosynthesis, and is believed to reduce ![]() Statins are widely used and well tolerated cholesterol-lowering drugs, and when used for therapy purposes reduce morbidityĪnd mortality from coronary heart disease. ![]()
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January 2023
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